CAUTION:
The following material regarding vitamin, mineral, amino acid and other dietary supplements is presented for purposes of information only, and is in no way intended to supersede advice from a qualified health care professional. Unless you have in-depth knowledge of these supplements and know what you are doing, it is strongly recommended that you consult your pharmacist or physician before attempting to medicate yourself. The Brain Chemistry Plan describes each supplement, its actions, uses, and contraindications - all of which are beyond the scope of this synopsis.

Responses to vitamin and mineral supplements can be highly idiosyncratic. In elevated dosage, for example, niacin (nicotinic acid) causes histamine release, resulting in cutaneous vasodilatation and increased blood flow, with symptoms of flushing, itching and tingling sensations, an increase in skin temperature, and increased motility of the stomach. These effects are transient, usually occurring a few minutes after ingestion and lasting up to an hour. Adverse reactions may include severe generalized flushing, decreased glucose tolerance, activation of peptic ulcers, abnormalities of hepatic function tests, jaundice, gastrointestinal disorders, dry skin, keratosis nigricans, pruritis, hyperuricemia, toxic amblyopia, hypotension and transient headache. When properly used, however, in conjunction with a high-protein diet, niacin is extremely effective.

If I had to choose only one vitamin [in] my repertoire for improving mood or guarding against the blues,
[niacin] is the one I'd probably pick. (p.71)